Steve Carell

as Gru / Dru (voice)

Kristen Wiig

as Lucy Wilde (voice)

Trey Parker

as Balthazar Bratt (voice)

Miranda Cosgrove

as Margo (voice)

Dana Gaier

as Edith (voice)

Nhev Scharrel

as Agnes (voice)

Pierre Coffin

as Mel / Minions / Museum Director / Additional Voice (voice)

Steve Coogan

as Fritz / Silas Ramsbottom (voice)

Julie Andrews

as Gru’s Mom (voice)

Kyle Balda

Director

Pierre Coffin

Director