Steve Carell

as Gru (voice)

Kristen Wiig

as Lucy (voice)

Benjamin Bratt

as Eduardo / El Macho (voice)

Miranda Cosgrove

as Margo (voice)

Dana Gaier

as Edith (voice)

Elsie Fisher

as Agnes (voice)

Russell Brand

as Dr. Nefario (voice)

Ken Jeong

as Floyd (voice)

Steve Coogan

as Silas (voice)

Pierre Coffin

Director

Chris Renaud

Director