Bradley Cooper

as Stanton Carlisle

Cate Blanchett

as Dr. Lilith Ritter

Toni Collette

as Zeena the Seer

Willem Dafoe

as Clem Hoatley

Richard Jenkins

as Ezra Grindle

Rooney Mara

as Molly Cahill

Ron Perlman

as Bruno

Mary Steenburgen

as Mrs. Kimball

David Strathairn

as Pete

Guillermo del Toro

Director