Keith Ferguson

as Megamind (voice)

Laura Post

as Roxanne Ritchi (voice)

Josh Brener

as Ol' Chum (voice)

Maya Tuttle

as Keiko Morita (voice)

Adam Lambert

as Machiavillain (voice)

Emily Tunon

as Lady Doppler (voice)

Talon Warburton

as Lord Nighty-Knight (voice)

Scott Adsit

as Pierre Pressure (voice)

Chris Sullivan

as Behemoth (voice)

Tony Hale

as Mel / Mr. Donut (voice)

Brent Simons

Creator

Alan Schoolcraft

Creator