Storm Reid

as Meg Murry

Oprah Winfrey

as Mrs. Which

Reese Witherspoon

as Mrs. Whatsit

Mindy Kaling

as Mrs. Who

Levi Miller

as Calvin O'Keefe

Deric McCabe

as Charles Wallace Murry

Chris Pine

as Dr. Alex Murry

Gugu Mbatha-Raw

as Dr. Kate Murry

Zach Galifianakis

as The Happy Medium

Ava DuVernay

Director